Markers of autoimmunity in immune thrombocytopenia: prevalence and prognostic significance
نویسندگان
چکیده
منابع مشابه
Clinical Significance of Positive Platelet Immunofluorescence Assay in Adult Immune Thrombocytopenia: a Cross Sectional Study
Background: Immune thrombocytopenia is a hematologic disorder characterized by low platelet count and variable bleeding manifestations due to immune-mediated platelet destruction and/or suppression of platelet production. This study was performed to evaluate characteristics and clinical presentations of adult patients with immune thrombocytopenia and to explore the clinical value of platelet an...
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OBJECTIVES To clarify clinical manifestations, association with disease activity, and prognostic impact of thrombocytopenia using simple and reliable indices. METHODS 632 patients were reviewed retrospectively. Fifty patients with thrombocytopenia were included as cases and matched with 100 control patients. Clinical manifestations at first thrombocytopenic episode were recorded. Classificati...
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MicroRNAs (miRNAs) are small preserved non-coding RNA molecules that regulate gene expression post-transcriptionally by targeting the 3' UTR of mRNAs for translational repression or degradation. The rising evidence has established the significant role of miRNAs within the regulation of immune system and the prevention of autoimmunity. MiR-146a has obtained an importance as a modulator of differ...
متن کاملsignificance of periodontal health in primary immune thrombocytopenia- a case report and review of literature.
primary immune thrombocytopenia is an acquired bleeding disorder with no clinically apparent cause of thrombocytopenia. clinical indicators of itp include easy bruising of the skin, prolonged bleeding on injury, mucocutaneous lesions such as petechiae and ecchymosis, epistaxis, gastrointestinal bleeding, hematuria and bleeding from the gums. it is important for a dentist to be aware of the clin...
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ژورنال
عنوان ژورنال: Blood Advances
سال: 2019
ISSN: 2473-9529,2473-9537
DOI: 10.1182/bloodadvances.2019000400